Single-cell profiling identifies distinct hormonal, immunologic, and inflammatory signatures of endometriosis-constituting cells

Type: Article

Published: September 8, 2023

Journal: The Journal of Pathology

DOI: https://doi.org/10.1002/path.6178

Image: BioRender

Takeaways

Various cell types, including endometrial, lymphoid, macrophage, fibroblast, and endothelial cells, are altered in endometriosis patients.

There are different endometriosis subtypes in which endometriosis cells show estrogen responsiveness, immunologic cytotoxicity and exhaustion, and proinflammation signatures differently.

Novel endometriosis-specific findings of MUC5B+ EEECs, mesothelial cell-derived myofibroblasts, and NRG1-ERBB3 interaction may contribute to the pathogenesis of endometriosis.

Results increase understanding of pathology, can help examine aggressive disease, and identify new therapeutic targets.

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